Title : Glucose promotes breast cancer aggression and reduces metformin efficacy.

Pub. Date : 2013 Dec 15

PMID : 24107633






2 Functional Relationships(s)
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1 Mechanisms of metformin action at normal vs. high glucose overlapped but were not identical; for example, metformin reduced IGF-1R expression in both the HER2+ SK-BR-3 and TNBC MDA-MB-468 cell lines more significantly at 5, as compared with 10 mmol/L glucose. Metformin erb-b2 receptor tyrosine kinase 2 Homo sapiens
2 Mechanisms of metformin action at normal vs. high glucose overlapped but were not identical; for example, metformin reduced IGF-1R expression in both the HER2+ SK-BR-3 and TNBC MDA-MB-468 cell lines more significantly at 5, as compared with 10 mmol/L glucose. Metformin erb-b2 receptor tyrosine kinase 2 Homo sapiens