Title : Activation of α2 adrenoceptors inhibited NMDA receptor-mediated nociceptive transmission in spinal dorsal horn of mice with inflammatory pain.

Pub. Date : 2014 Feb

PMID : 24103367






3 Functional Relationships(s)
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1 Whole-cell patch clamp recordings in lamina II neurons illustrated that clonidine significantly decreased the amplitudes of NMDAR-mediated monosynaptic responses in inflamed mice through activation of alpha2A-subtype adrenoceptor. Clonidine glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus
2 Intracellular loading of nonhydrolyzable GDP analog GDP-beta-S blocked, whereas direct inhibition of cAMP-dependent protein kinase (PKA) mimicked, the inhibitory effect of clonidine on NMDAR currents, implicating that Galphai protein/PKA signaling was involved in clonidine action. Clonidine glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus
3 Biochemical analysis in vivo revealed that intrathecal clonidine administration specifically decreased the content of GluN2B subunit-containing NMDAR at synaptosomal membrane fraction, a result associated closely with the alleviation of inflammatory pain. Clonidine glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus