Pub. Date : 2014 Feb
PMID : 24103367
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Whole-cell patch clamp recordings in lamina II neurons illustrated that clonidine significantly decreased the amplitudes of NMDAR-mediated monosynaptic responses in inflamed mice through activation of alpha2A-subtype adrenoceptor. | Clonidine | glutamate receptor, ionotropic, NMDA1 (zeta 1) | Mus musculus |
2 | Intracellular loading of nonhydrolyzable GDP analog GDP-beta-S blocked, whereas direct inhibition of cAMP-dependent protein kinase (PKA) mimicked, the inhibitory effect of clonidine on NMDAR currents, implicating that Galphai protein/PKA signaling was involved in clonidine action. | Clonidine | glutamate receptor, ionotropic, NMDA1 (zeta 1) | Mus musculus |
3 | Biochemical analysis in vivo revealed that intrathecal clonidine administration specifically decreased the content of GluN2B subunit-containing NMDAR at synaptosomal membrane fraction, a result associated closely with the alleviation of inflammatory pain. | Clonidine | glutamate receptor, ionotropic, NMDA1 (zeta 1) | Mus musculus |