Pub. Date : 2013
PMID : 24098639
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | New potential therapeutic approach for the treatment of B-Cell malignancies using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticles. | Chlorambucil | keratin 20 | Homo sapiens |
| 2 | In this contribution, we propose a novel therapeutic approach in which relatively high doses of Hydroxychloroquine and Chlorambucil were loaded into biodegradable nanoparticles coated with an anti-CD20 antibody. | Chlorambucil | keratin 20 | Homo sapiens |
| 3 | In vitro and in vivo data showed the ability of anti-CD20 nanoparticles loaded with Hydroxychloroquine and Chlorambucil to increase tumor cell killing in comparison to free cytotoxic agents or Rituximab. | Chlorambucil | keratin 20 | Homo sapiens |
| 4 | These results shed light on the potential of anti-CD20 nanoparticles carrying Hydroxychloroquine and Chlorambucil for controlling a disseminated model of aggressive lymphoma, and lend credence to the idea of adopting this therapeutic approach for the treatment of B-cell disorders. | Chlorambucil | keratin 20 | Homo sapiens |