Pub. Date : 2013
PMID : 24098536
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. | sphingosine 1-phosphate | phosphatase and tensin homolog | Homo sapiens |
| 2 | We found that acid ceramidase promotes a reduction in nuclear PTEN that is dependent upon sphingosine 1-phosphate-mediated activation of Akt. | sphingosine 1-phosphate | phosphatase and tensin homolog | Homo sapiens |
| 3 | We were further able to show that sphingosine 1-phosphate promotes formation of a complex between Crm1 and PTEN, and that leptomycin B prevents acid ceramidase and sphingosine 1-phosphate mediated loss of nuclear PTEN, suggesting an active exportin-mediated event. | sphingosine 1-phosphate | phosphatase and tensin homolog | Homo sapiens |
| 4 | We were further able to show that sphingosine 1-phosphate promotes formation of a complex between Crm1 and PTEN, and that leptomycin B prevents acid ceramidase and sphingosine 1-phosphate mediated loss of nuclear PTEN, suggesting an active exportin-mediated event. | sphingosine 1-phosphate | phosphatase and tensin homolog | Homo sapiens |
| 5 | These findings suggest that acid ceramidase, through sphingosine 1-phosphate, promotes nuclear export of PTEN as a means of promoting tumor formation, cell proliferation, and resistance to therapy. | sphingosine 1-phosphate | phosphatase and tensin homolog | Homo sapiens |