Title : Suppression of Alzheimer's disease-related phenotypes by geranylgeranylacetone in mice.

Pub. Date : 2013

PMID : 24098472






3 Functional Relationships(s)
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1 Repeated oral administration of geranylgeranylacetone to APP23 mice for 9 months not only improved cognitive function but also decreased levels of Abeta, Abeta plaque deposition and synaptic loss. geranylgeranylacetone amyloid beta (A4) precursor protein Mus musculus
2 Repeated oral administration of geranylgeranylacetone to APP23 mice for 9 months not only improved cognitive function but also decreased levels of Abeta, Abeta plaque deposition and synaptic loss. geranylgeranylacetone amyloid beta (A4) precursor protein Mus musculus
3 Although the repeated oral administration of geranylgeranylacetone did not increase the level of HSP70 in the brain, a single oral administration of geranylgeranylacetone significantly increased the level of HSP70 when Abeta was concomitantly injected directly into the hippocampus. geranylgeranylacetone amyloid beta (A4) precursor protein Mus musculus