Title : Effects of salicylate on the inflammatory genes expression and synaptic ultrastructure in the cochlear nucleus of rats.

Pub. Date : 2014 Apr

PMID : 24092407






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 GPIAS showed that rats with long-term administration of salicylate were experiencing tinnitus, and the mRNA and protein expression levels of TNF-alpha and NR2A were up-regulated in chronic treatment groups, and they returned to baseline 14 days after cessation of treatment. Salicylates glutamate ionotropic receptor NMDA type subunit 2A Rattus norvegicus
2 These data revealed that chronic salicylate administration markedly, but reversibly, induces tinnitus possibly via augmentation of the expression of TNF-alpha and NR2A and cause changes in synaptic ultrastructure in the CN. Salicylates glutamate ionotropic receptor NMDA type subunit 2A Rattus norvegicus