Pub. Date : 2014 Mar
PMID : 24079644
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In these cells, caspase-3 was inhibited by ceramide-induced Akt phosphorylation, and by the induction of autophagic microtubule-associated protein-1 light-chain 3 lipidation. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | In cells from smokers, the prominent up-regulation of Akt pathways inhibited ceramide-triggered apoptosis, and was associated with elevated sphingosine and high-mobility group box 1, skewing the cell"s response toward autophagy and survival. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | In conclusion, the cell responses to ceramide are modulated by an intricate cross-talk between Akt signaling and sphingolipid metabolites, and profoundly modified by previous cigarette smoke exposure, which selects for an apoptosis-resistant phenotype. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |