Title : Increased mammalian target of rapamycin complex 2 signaling promotes age-related decline in CD4 T cell signaling and function.

Pub. Date : 2013 Nov 1

PMID : 24078700






1 Functional Relationships(s)
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1 In this study, we demonstrate that aging increases TORC2 signaling in murine CD4 T cells, a change blocked by long-term exposure to rapamycin, suggesting that functional defects may be the result of enhanced TORC2 function. Sirolimus CD4 antigen Mus musculus