Pub. Date : 2013 Nov 8
PMID : 24078627
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The CHOP binding site on the DR5 gene was required for induction of DR5 by azadirone. | azadirone | TNF receptor superfamily member 10b | Homo sapiens |
2 | The CHOP binding site on the DR5 gene was required for induction of DR5 by azadirone. | azadirone | TNF receptor superfamily member 10b | Homo sapiens |
3 | Overall, this study indicates that azadirone can sensitize cancer cells to TRAIL through ROS-ERK-CHOP-mediated up-regulation of DR5 and DR4 signaling, down-regulation of cell survival proteins, and up-regulation of proapoptotic proteins. | azadirone | TNF receptor superfamily member 10b | Homo sapiens |