Title : Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway.

Pub. Date : 2013 Nov 8

PMID : 24078627






3 Functional Relationships(s)
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Protein Name
Organism
1 The CHOP binding site on the DR5 gene was required for induction of DR5 by azadirone. azadirone TNF receptor superfamily member 10b Homo sapiens
2 The CHOP binding site on the DR5 gene was required for induction of DR5 by azadirone. azadirone TNF receptor superfamily member 10b Homo sapiens
3 Overall, this study indicates that azadirone can sensitize cancer cells to TRAIL through ROS-ERK-CHOP-mediated up-regulation of DR5 and DR4 signaling, down-regulation of cell survival proteins, and up-regulation of proapoptotic proteins. azadirone TNF receptor superfamily member 10b Homo sapiens