Title : Ursolic acid induces apoptosis of SW480 cells via p53 activation.

Pub. Date : 2013 Dec

PMID : 24071474






2 Functional Relationships(s)
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1 In addition, the expression levels of p-p53, acetyl-p53, NF-kappaB, p-p21, Bax, Caspase-3 and Caspase-9, apoptotic proteins, were increased in cells treated with ursolic acid compared to blank group. ursolic acid nuclear factor kappa B subunit 1 Homo sapiens
2 Above results demonstrate that ursolic acid induces the activation of p53, NF-kappaB and Bax, leading to the enhancement of p21 transcriptional activity and activation of Caspase-9 and -3, thus finally induces apoptosis of SW480 cells. ursolic acid nuclear factor kappa B subunit 1 Homo sapiens