Pub. Date : 2014
PMID : 24067162
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Telmisartan increases lipoprotein lipase expression via peroxisome proliferator-activated receptor-alpha in HepG2 cells. | Telmisartan | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 2 | In this study, we assessed the effect of telmisartan on the expression of PPAR-alpha and lipoprotein lipase (LPL). | Telmisartan | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 3 | PPAR-alpha expression was detected by reverse-transcription polymerase chain reaction and Western blot in HepG2 hepatocytes as well as differentiated C2C12 myocytes treated with increasing concentrations of telmisartan (0.1-10 mumol/L) for 48 h. Results showed that 1 mumol/L and 10 mumol/L telmisartan significantly increased the expression of PPAR-alpha mRNA and protein in HepG2 cells (p < 0.01). | Telmisartan | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 4 | PPAR-alpha expression was detected by reverse-transcription polymerase chain reaction and Western blot in HepG2 hepatocytes as well as differentiated C2C12 myocytes treated with increasing concentrations of telmisartan (0.1-10 mumol/L) for 48 h. Results showed that 1 mumol/L and 10 mumol/L telmisartan significantly increased the expression of PPAR-alpha mRNA and protein in HepG2 cells (p < 0.01). | Telmisartan | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 5 | Similarly, 1 micromol/L and 10 mumol/L telmisartan significantly increased the expression of LPL mRNA and protein in HepG2 cells (p < 0.01), and this increase was significantly (p < 0.01) inhibited by the PPAR-alpha-specific antagonist MK886. | Telmisartan | peroxisome proliferator activated receptor alpha | Homo sapiens |