Title : The N-terminal flanking region of the A1 domain regulates the force-dependent binding of von Willebrand factor to platelet glycoprotein IbĪ±.

Pub. Date : 2013 Nov 8

PMID : 24062306






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The VWF A1 domain that contains the N-terminal flanking sequence Gln(1238)-Glu(1260) (1238-A1) formed triphasic slip-catch-slip bonds with GPIbalpha. Glutamic Acid von Willebrand factor Homo sapiens
2 Soluble Gln(1238)-Glu(1260) reduced the lifetimes of GPIbalpha bonds with VWF and 1238-A1 but rescued the catch bond of GPIbalpha with 1261-A1. Glutamic Acid von Willebrand factor Homo sapiens