Title : Design and exploratory neuropharmacological evaluation of novel thyrotropin-releasing hormone analogs and their brain-targeting bioprecursor prodrugs.

Pub. Date : 2013

PMID : 24058724






2 Functional Relationships(s)
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1 We report here novel and metabolically stable analogs that we derived from TRH by replacing its amino-terminal pyroglutamyl (pGlu) residue with pyridinium-containing moieties. Pyrrolidonecarboxylic Acid thyrotropin releasing hormone Mus musculus
2 On the other hand, the loss of potency compared to TRH in a model testing antidepressant-like effect with a simultaneous preservation of analeptic activity has been observed, when pGlu was replaced with trigonelloyl residue. Pyrrolidonecarboxylic Acid thyrotropin releasing hormone Mus musculus