Title : p85-RhoGDI2, a novel complex, is required for PSGL-1-induced β1 integrin-mediated lymphocyte adhesion to VCAM-1.

Pub. Date : 2013 Dec

PMID : 24055812






1 Functional Relationships(s)
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1 Phosporylations of the p85-bound Rho-GDP dissociation inhibitor-2 on 130 and 153 tyrosine residues by c-Abl and Src were required for the complex to be recruited to P-selectin glycoprotein ligand-1 and thereby regulate beta1 integrin-mediated T cell adhesion to vascular cell adhesion molecule-1. Tyrosine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens