Title : Triphenylphosphonium salts of 1,2,4-benzothiadiazine 1,1-dioxides related to diazoxide targeting mitochondrial ATP-sensitive potassium channels.

Pub. Date : 2013 Nov 1

PMID : 24055044






1 Functional Relationships(s)
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1 Previous works revealed that the presence of an (R)-1-hydroxy-2-propylamino chain at the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides KATP channel openers increased, in most cases, the selectivity towards the pancreatic-type (SUR1/Kir6.2) KATP channel. 4h-1,2,4-benzothiadiazine 1,1-dioxides potassium inwardly-rectifying channel, subfamily J, member 11 Rattus norvegicus