Protein Name potassium inwardly-rectifying channel, subfamily J, member 11
Organism Rattus norvegicus
Gene ID 83535
Gene Symbol

Kcnj11

UniProt P70673 (KCJ11_RAT)
Relationships Total Number of functionally related compound(s) : 89
Total Number of Articles : 93
Description

potassium inwardly-rectifying channel, subfamily J, member 11

Gene Summary

Enables several functions, including ankyrin binding activity; inorganic cation transmembrane transporter activity; and protein C-terminus binding activity. Involved in several processes, including cation transport; cellular response to nicotine; and response to ischemia. Located in several cellular components, including axolemma; cell body fiber; and cytoplasmic vesicle. Part of inward rectifying potassium channel. Biomarker of brain disease (multiple); glucose metabolism disease (multiple); hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 2 and glucose metabolism disease (multiple). Orthologous to human KCNJ11 (potassium inwardly rectifying channel subfamily J member 11). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • ATP-sensitive inward rectifier potassium channel 11
  • BIR
  • inward rectifier K(+) channel Kir6.2
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Properties