Pub. Date : 2014 Jan 10
PMID : 24053613
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension. | Superoxides | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 2 | AIMS: Angiotensin II (AngII)-induced superoxide (O2( -)) production by the NADPH oxidases and mitochondria has been implicated in the pathogenesis of endothelial dysfunction and hypertension. | Superoxides | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 3 | AIMS: Angiotensin II (AngII)-induced superoxide (O2( -)) production by the NADPH oxidases and mitochondria has been implicated in the pathogenesis of endothelial dysfunction and hypertension. | Superoxides | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 4 | AIMS: Angiotensin II (AngII)-induced superoxide (O2( -)) production by the NADPH oxidases and mitochondria has been implicated in the pathogenesis of endothelial dysfunction and hypertension. | Superoxides | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 5 | AIMS: Angiotensin II (AngII)-induced superoxide (O2( -)) production by the NADPH oxidases and mitochondria has been implicated in the pathogenesis of endothelial dysfunction and hypertension. | Superoxides | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 6 | Nox2 depletion in gp91phox knockout mice inhibited AngII-induced cellular and mitochondrial O2( -) and attenuated hypertension. | Superoxides | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 7 | Inhibition of mitochondrial reverse electron transfer with malonate, malate, or rotenone attenuated AngII-induced cytoplasmic and mitochondrial O2( -) production. | Superoxides | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 8 | Inhibition of the mitochondrial ATP-sensitive potassium channel (mitoK(+)ATP) with 5-hydroxydecanoic acid or specific PKCe peptide antagonist (EAVSLKPT) reduced AngII-induced H2O2 in isolated mitochondria and diminished cytoplasmic O2( -). | Superoxides | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 9 | Mitochondria-targeted H2O2 scavenger mitoEbselen attenuated redox-dependent c-Src and inhibited AngII-induced cellular O2( -), diminished aortic H2O2, and reduced blood pressure in hypertensive mice. | Superoxides | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |