Title : Implication of NADPH oxidases in the early inflammation process generated by cystic fibrosis cells.

Pub. Date : 2012

PMID : 24049649






1 Functional Relationships(s)
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1 Nevertheless, several parameters participating in oxidative stress (increased ROS production and apoptosis, decreased total thiol content) were observed in IB3-1 cells cultured in hypertonic environment as compared to S9 cells and were inhibited by diphenyleneiodonium (DPI), a well-known inhibitor of NOXs; besides, increased production of the proinflammatory cytokines IL-6 and IL-8 by IB3-1 cells was also inhibited by DPI as compared to S9 cells. diphenyleneiodonium interleukin 6 Homo sapiens