Title : Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization.

Pub. Date : 2013 Sep 17

PMID : 24044575






2 Functional Relationships(s)
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1 Expression of chemokine for monocytes (CSF-1 and CCL-2) were low in tumor cells from EGCG-treated mice, and cytokines of TAM was skewed from M2- into M1-like phenotype by EGCG as evidenced by decreased IL-6 and TGF-beta and increased TNF-alpha. epigallocatechin gallate interleukin 6 Mus musculus
2 Ex vivo incubation of TAM with exosomes from EGCG-treated 4T1 cells led to IKKalpha suppression and concomitant I-kappaB accumulation; increase of IL-6 and TGF-beta; and, decrease of TNF-alpha. epigallocatechin gallate interleukin 6 Mus musculus