Pub. Date : 2013 Oct 25
PMID : 24036112
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We previously demonstrated that the mTORC1/S6K1 pathway is activated by insulin and nutrient overload (e.g. amino acids (AA)), which leads to the inhibition of the PI3K/Akt pathway via the inhibitory serine phosphorylation of IRS-1, notably on serine 1101 (Ser-1101). | Serine | insulin receptor substrate 1 | Rattus norvegicus |
| 2 | We previously demonstrated that the mTORC1/S6K1 pathway is activated by insulin and nutrient overload (e.g. amino acids (AA)), which leads to the inhibition of the PI3K/Akt pathway via the inhibitory serine phosphorylation of IRS-1, notably on serine 1101 (Ser-1101). | Serine | insulin receptor substrate 1 | Rattus norvegicus |
| 3 | We previously demonstrated that the mTORC1/S6K1 pathway is activated by insulin and nutrient overload (e.g. amino acids (AA)), which leads to the inhibition of the PI3K/Akt pathway via the inhibitory serine phosphorylation of IRS-1, notably on serine 1101 (Ser-1101). | Serine | insulin receptor substrate 1 | Rattus norvegicus |
| 4 | However, even in the absence of AA, insulin can still promote IRS-1 Ser-1101 phosphorylation by other kinases that remain to be fully characterized. | Serine | insulin receptor substrate 1 | Rattus norvegicus |
| 5 | Computational analyses revealed that Ser-1101 within IRS-1 falls into the consensus motif of RSK. | Serine | insulin receptor substrate 1 | Rattus norvegicus |
| 6 | Moreover, recombinant RSK phosphorylated IRS-1 C-terminal fragment on Ser-1101, which was prevented by mutations of this site or when a kinase-inactive mutant of RSK was used. | Serine | insulin receptor substrate 1 | Rattus norvegicus |
| 7 | Inhibition of RSK using either the pharmacological inhibitor BI-D1870 or after adenoviral expression of a dominant negative RSK1 mutant (RSK1-DN) showed that RSK selectively phosphorylates IRS-1 on Ser-1101. | Serine | insulin receptor substrate 1 | Rattus norvegicus |
| 8 | These results show that RSK is a novel regulator of insulin signaling and glucose metabolism and a potential mediator of insulin resistance, notably through the negative phosphorylation of IRS-1 on Ser-1101. | Serine | insulin receptor substrate 1 | Rattus norvegicus |