Pub. Date : 2014 Feb
PMID : 24033439
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phosphorylation of tau protein at sites Ser(396-404) is one of the earliest events in Alzheimer"s disease and Down syndrome. | Serine | microtubule associated protein tau | Homo sapiens |
| 2 | METHODS: Immunohistochemistry for modified tau [phosphorylated at Ser(199-202) -Thr(205) (AT8) and Ser(396-404) (PHF-1) or truncated at D(421) (TauC3) and E(391) (MN423)] was performed on paraffin-embedded human brain sections. | Serine | microtubule associated protein tau | Homo sapiens |
| 3 | Around 50% of the total structures containing phosphorylation at sites Ser(396-404) were found as early phospho-tau aggregates with a well-preserved neuronal soma. | Serine | microtubule associated protein tau | Homo sapiens |
| 4 | Phosphorylation of tau protein at sites Ser(396) coexists with early and late truncation events. | Serine | microtubule associated protein tau | Homo sapiens |