Title : Gfi-1 is the transcriptional repressor of SOCS1 in acute myeloid leukemia cells.

Pub. Date : 2014 Jan

PMID : 24018353






1 Functional Relationships(s)
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1 By ChIP assay, we demonstrated that G9a and SUV39H1, two enzymes catalyzing H3K9 methylation, were physically associated with the SOCS1 promoter, and treatment with chaetocin, a histone methyltransferase inhibitor, suppressed H3K9 methylation on the SOCS1 promoter and enhanced SOCS1 expression. chaetocin euchromatic histone lysine methyltransferase 2 Homo sapiens