Title : Evidence for two modes of synergistic induction of apoptosis by mapatumumab and oxaliplatin in combination with hyperthermia in human colon cancer cells.

Pub. Date : 2013

PMID : 24013390






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Death signaling was activated by c-Jun N-terminal kinase (JNK) signaling which led to Bcl-xL phosphorylation at serine 62, decreasing the anti-apoptotic activity of Bcl-xL, which contributed to the intrinsic pathway. Serine mitogen-activated protein kinase 8 Homo sapiens
2 Death signaling was activated by c-Jun N-terminal kinase (JNK) signaling which led to Bcl-xL phosphorylation at serine 62, decreasing the anti-apoptotic activity of Bcl-xL, which contributed to the intrinsic pathway. Serine mitogen-activated protein kinase 8 Homo sapiens