Pub. Date : 2014 Jul 3
PMID : 24013224
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosis. | Doxorubicin | TNF superfamily member 10 | Homo sapiens |
| 2 | Chemotherapeutic agents, such as doxorubicin have been shown to act synergistically with TRAIL, but the exact mechanisms of actions are poorly understood. | Doxorubicin | TNF superfamily member 10 | Homo sapiens |
| 3 | In this study, we performed high-throughput small interfering RNA screening and genome-wide gene expression profiling on doxorubicin-treated U1690 cells to explore novel mechanisms underlying doxorubicin-TRAIL synergy. | Doxorubicin | TNF superfamily member 10 | Homo sapiens |
| 4 | In this study, we performed high-throughput small interfering RNA screening and genome-wide gene expression profiling on doxorubicin-treated U1690 cells to explore novel mechanisms underlying doxorubicin-TRAIL synergy. | Doxorubicin | TNF superfamily member 10 | Homo sapiens |