Title : c-Myc-mediated epigenetic silencing of MicroRNA-101 contributes to dysregulation of multiple pathways in hepatocellular carcinoma.

Pub. Date : 2014 May

PMID : 24002871






2 Functional Relationships(s)
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1 miR-101, in turn, inhibits the expression of two subunits of PRC2 (EZH2 and EED), thus creating a double-negative feedback loop that regulates the process of hepatocarcinogenesis. mir-101 enhancer of zeste 2 polycomb repressive complex 2 subunit Homo sapiens
2 In addition, co-overexpression of c-Myc and EZH2 in HCC samples was closely associated with lower expression of miR-101 (P < 0.0001) and poorer prognosis of HCC patients (P < 0.01). mir-101 enhancer of zeste 2 polycomb repressive complex 2 subunit Homo sapiens