Pub. Date : 2013 Dec
PMID : 23988737
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dehydroepiandrosterone sulfate (DHEAS) is a circulating steroid produced in the adrenal cortex, brain, and gonads. | Steroids | sulfotransferase family 2A member 1 | Homo sapiens |
| 2 | The fact, however, that steroid sulfatase mRNA was not detected in the GC-2 cells and the clear demonstration of DHEAS-induced activation of Erk1/2, ATF-1 and CREB after silencing the androgen receptor by small interfering RNA (siRNA) clearly contradict this assumption and make it appear unlikely that DHEAS has to be converted in the cytosol into a different steroid in order to activate the kinases and transcription factors mentioned. | Steroids | sulfotransferase family 2A member 1 | Homo sapiens |
| 3 | Instead, it is likely that the DHEAS-induced signaling is mediated through the interaction of the steroid with a membrane-bound G-protein-coupled receptor, since silencing of Guanine nucleotide-binding protein subunit alpha-11 (Gnalpha11) leads to the abolition of the DHEAS-induced stimulation of Erk1/2, ATF-1, and CREB. | Steroids | sulfotransferase family 2A member 1 | Homo sapiens |
| 4 | Instead, it is likely that the DHEAS-induced signaling is mediated through the interaction of the steroid with a membrane-bound G-protein-coupled receptor, since silencing of Guanine nucleotide-binding protein subunit alpha-11 (Gnalpha11) leads to the abolition of the DHEAS-induced stimulation of Erk1/2, ATF-1, and CREB. | Steroids | sulfotransferase family 2A member 1 | Homo sapiens |