Title : Effects of decreased vitamin D and accumulated uremic toxin on human CYP3A4 activity in patients with end-stage renal disease.

Pub. Date : 2013 Aug 19

PMID : 23965431






2 Functional Relationships(s)
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1 Furthermore, addition of 1,25-dihydroxyvitamin D to uremic serum partially restored the serum effect on CYP3A4 expression. 1,25-dihydroxyvitamin D cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 The present study suggests that the decrease of 1,25-dihydroxyvitamin D and the accumulation of uremic toxins contributed to the decreased hepatic clearance of CYP3A4 substrates in patients with end-stage renal disease. 1,25-dihydroxyvitamin D cytochrome P450 family 3 subfamily A member 4 Homo sapiens