Title : Differential recognition of syk-binding sites by each of the two phosphotyrosine-binding pockets of the Vav SH2 domain.

Pub. Date : 2013 Nov

PMID : 23955592






1 Functional Relationships(s)
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1 The association of spleen tyrosine kinase (Syk), a central tyrosine kinase in B cell signaling, with Vav SH2 domain is controlled by phosphorylation of two closely spaced tyrosines in Syk linker B: Y342 and Y346. Tyrosine vav guanine nucleotide exchange factor 1 Homo sapiens