Title : Dual contradictory effect of H-89 on neuronal retraction, death and inflammation in differentiated PC12 cells subjected to oxidative stress.

Pub. Date : 2013 Nov

PMID : 23949609






2 Functional Relationships(s)
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1 In this study, we investigated the effect of H-89, a selective inhibitor of PKA, on the neurite retraction along with evaluation of cell death and inflammatory markers in the differentiated PC12 cells, exposed to H2O2. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus
2 We found that dose-dependent inhibition of PKA by low and medium concentrations of H-89 (5, 7 and 10 muM) enhanced the parameters of neurite outgrowth and complexity in the cells co-treated with H2O2 as an oxidative stress. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus