Title : Soluble interleukin-6 receptor-mediated innate immune response to DNA and RNA viruses.

Pub. Date : 2013 Oct

PMID : 23946454






2 Functional Relationships(s)
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1 Furthermore, sIL6R mediated antiviral action via the p28 pathway and induced alpha interferon (IFN-alpha) by promoting the nuclear translocation of IFN regulatory factor 3 (IRF3) and NF-kappaB, which led to the activation of downstream IFN effectors, including 2",5"-oligoadenylate synthetase (OAS), double-stranded RNA-dependent protein kinase (PKR), and myxovirus resistance protein (Mx). sil6r interferon regulatory factor 3 Homo sapiens
2 Furthermore, sIL6R mediated antiviral action via the p28 pathway and induced alpha interferon (IFN-alpha) by promoting the nuclear translocation of IFN regulatory factor 3 (IRF3) and NF-kappaB, which led to the activation of downstream IFN effectors, including 2",5"-oligoadenylate synthetase (OAS), double-stranded RNA-dependent protein kinase (PKR), and myxovirus resistance protein (Mx). sil6r interferon regulatory factor 3 Homo sapiens