| Protein Name | interferon regulatory factor 3 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 3661 |
| Gene Symbol | IRF3 |
| UniProt | Q14653 (IRF3_HUMAN), M0QYT9 (M0QYT9_HUMAN), E2GIM7 (E2GIM7_HUMAN), E2GIM9 (E2GIM9_HUMAN), E2GIM6 (E2GIM6_HUMAN), E2GIM5 (E2GIM5_HUMAN), E2GIM8 (E2GIM8_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
210
Total Number of Articles : 338 |
Description |
interferon regulatory factor 3 |
| Gene Summary |
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2020] |
| synonyms |
|
| Properties | |