Title : A highly selective dual insulin receptor (IR)/insulin-like growth factor 1 receptor (IGF-1R) inhibitor derived from an extracellular signal-regulated kinase (ERK) inhibitor.

Pub. Date : 2013 Sep 27

PMID : 23935097






1 Functional Relationships(s)
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1 Biochemical and structural studies indicate that this class achieves its high selectivity by binding to the ATP-binding pocket of inactive, unphosphorylated IGF-1R/IR and stabilizing the activation loop in a native-like inactive conformation. Adenosine Triphosphate insulin receptor Homo sapiens