Title : Bimodal concentration-response of nicotine involves the nicotinic acetylcholine receptor, transient receptor potential vanilloid type 1, and transient receptor potential ankyrin 1 channels in mouse trachea and sensory neurons.

Pub. Date : 2013 Nov

PMID : 23926288






2 Functional Relationships(s)
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1 High concentrations of nicotine, as in the saliva of oral tobacco consumers or in smoking cessation aids, have been shown to sensitize/activate recombinant transient receptor potential vanilloid type 1 (rTRPV1) and mouse TRPA1 (mTRPA1) channels. Nicotine transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus
2 The nicotine response at 20 mM was strongly pHe-dependent, - five times greater at pH 9.0 than 7.4, indicating that intracellular permeation of the (uncharged) alkaloid was required to reach the TRPV1/A1 binding sites. Nicotine transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus