Title : Celecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis.

Pub. Date : 2013

PMID : 23922700






2 Functional Relationships(s)
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1 The expressions of prostaglandin E2 (PGE2), phosphorylated extracellular signal-regulated kinase (p-ERK), hypoxia-inducible factor-1alpha (HIF-1alpha), and c-fos were also down-regulated after celecoxib treatment. Celecoxib hypoxia inducible factor 1 subunit alpha Rattus norvegicus
2 The anti-angiogenesis effect afforded by celecoxib may attribute to its modulation on VEGF/VEGFR-2 through the down-regulation of integrated signal pathways involving PGE2- HIF-1alpha- VEGF and p-ERK- c-fos- VEGFR-2. Celecoxib hypoxia inducible factor 1 subunit alpha Rattus norvegicus