Title : Celecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis.

Pub. Date : 2013

PMID : 23922700






3 Functional Relationships(s)
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1 Furthermore, the up-regulation of hepatic mRNA and protein levels of VEGF, VEGFR-2 and COX-2 induced by TAA was significantly inhibited after celecoxib treatment. Celecoxib kinase insert domain receptor Rattus norvegicus
2 The anti-angiogenesis effect afforded by celecoxib may attribute to its modulation on VEGF/VEGFR-2 through the down-regulation of integrated signal pathways involving PGE2- HIF-1alpha- VEGF and p-ERK- c-fos- VEGFR-2. Celecoxib kinase insert domain receptor Rattus norvegicus
3 The anti-angiogenesis effect afforded by celecoxib may attribute to its modulation on VEGF/VEGFR-2 through the down-regulation of integrated signal pathways involving PGE2- HIF-1alpha- VEGF and p-ERK- c-fos- VEGFR-2. Celecoxib kinase insert domain receptor Rattus norvegicus