Title : Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex.

Pub. Date : 2013 Aug 20

PMID : 23918382






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Brefeldin A-inhibited guanine nucleotide-exchange factors BIG1 and BIG2 activate, through their Sec7 domains, ADP ribosylation factors (Arfs) by accelerating the replacement of Arf-bound GDP with GTP for initiation of vesicular transport or activation of specific enzymes that modify important phospholipids. Guanine Nucleotides ADP ribosylation factor guanine nucleotide exchange factor 1 Homo sapiens