Protein Name ARF guanine nucleotide exchange factor 1
Organism Homo sapiens
Gene ID 10565
Gene Symbol

ARFGEF1

UniProt Q9Y6D6 (BIG1_HUMAN), A0A024R7X0 (A0A024R7X0_HUMAN)
Relationships Total Number of functionally related compound(s) : 31
Total Number of Articles : 36
Description

ARF guanine nucleotide exchange factor 1

Gene Summary

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011]

synonyms
  • brefeldin A-inhibited guanine nucleotide-exchange protein 1
  • ADP ribosylation factor guanine nucleotide exchange factor 1
  • ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
Click to show/hide the synonyms
Properties