Pub. Date : 2013 Aug 1
PMID : 23915702
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we show that increased sphingosine-1-phoshate (S1P) through direct injection or via the administration of the small molecule 2-acetyl-4(5)-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor, has beneficial effects in acutely injured dystrophic muscles of mdx mice. | 2-acetyl-4(5)-tetrahydroxybutylimidazole | sphingosine-1-phosphate receptor 1 | Mus musculus |
| 2 | Here we show that increased sphingosine-1-phoshate (S1P) through direct injection or via the administration of the small molecule 2-acetyl-4(5)-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor, has beneficial effects in acutely injured dystrophic muscles of mdx mice. | 2-acetyl-4(5)-tetrahydroxybutylimidazole | sphingosine-1-phosphate receptor 1 | Mus musculus |
| 3 | Here we show that increased sphingosine-1-phoshate (S1P) through direct injection or via the administration of the small molecule 2-acetyl-4(5)-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor, has beneficial effects in acutely injured dystrophic muscles of mdx mice. | 2-acetyl-4(5)-tetrahydroxybutylimidazole | sphingosine-1-phosphate receptor 1 | Mus musculus |
| 4 | Here we show that increased sphingosine-1-phoshate (S1P) through direct injection or via the administration of the small molecule 2-acetyl-4(5)-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor, has beneficial effects in acutely injured dystrophic muscles of mdx mice. | 2-acetyl-4(5)-tetrahydroxybutylimidazole | sphingosine-1-phosphate receptor 1 | Mus musculus |
| 5 | Here we show that increased sphingosine-1-phoshate (S1P) through direct injection or via the administration of the small molecule 2-acetyl-4(5)-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor, has beneficial effects in acutely injured dystrophic muscles of mdx mice. | 2-acetyl-4(5)-tetrahydroxybutylimidazole | sphingosine-1-phosphate receptor 1 | Mus musculus |
| 6 | Here we show that increased sphingosine-1-phoshate (S1P) through direct injection or via the administration of the small molecule 2-acetyl-4(5)-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor, has beneficial effects in acutely injured dystrophic muscles of mdx mice. | 2-acetyl-4(5)-tetrahydroxybutylimidazole | sphingosine-1-phosphate receptor 1 | Mus musculus |
| 7 | CONCLUSIONS: These data show that S1P is beneficial for muscle regeneration and functional gain in dystrophic mice, and that THI, or other pharmacological agents that raise S1P levels systemically, may be developed into an effective treatment for improving muscle function and reducing the pathology of DMD. | 2-acetyl-4(5)-tetrahydroxybutylimidazole | sphingosine-1-phosphate receptor 1 | Mus musculus |