Title : Depleted energy charge and increased pulmonary endothelial permeability induced by mitochondrial complex I inhibition are mitigated by coenzyme Q1 in the isolated perfused rat lung.

Pub. Date : 2013 Dec

PMID : 23912160






1 Functional Relationships(s)
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1 The amphipathic quinone coenzyme Q1 (CoQ1; 50 muM) mitigated the impact of rotenone on the adenine nucleotide balance, wherein mitigation was blocked by NAD(P)H-quinone oxidoreductase 1 or mitochondrial complex III inhibitors. quinone NAD(P)H quinone dehydrogenase 1 Rattus norvegicus