Title : Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists.

Pub. Date : 2013 Aug 22

PMID : 23909910






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Several members of this class inhibit NMDA receptor responses in the nanomolar range and are more than 50-fold selective over GluN1/GluN2A and GluN1/GluN2B NMDA receptors, as well as AMPA, kainate, GABA, glycine, nicotinic, serotonin, and purinergic receptors. Glycine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens
2 Several members of this class inhibit NMDA receptor responses in the nanomolar range and are more than 50-fold selective over GluN1/GluN2A and GluN1/GluN2B NMDA receptors, as well as AMPA, kainate, GABA, glycine, nicotinic, serotonin, and purinergic receptors. Glycine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens