Title : In silico and in vitro studies to elucidate the role of Cu2+ and galanthamine as the limiting step in the amyloid beta (1-42) fibrillation process.

Pub. Date : 2013 Oct

PMID : 23904252






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The formation of Abeta fibrils and oligomers requires a conformational change from an alpha-helix to a beta-sheet conformation, which is encouraged by the formation of a salt bridge between Asp 23 or Glu 22 and Lys 28. Aspartic Acid amyloid beta precursor protein Homo sapiens
2 Then, ligands that bind Asp 23 or Glu 22 and Lys 28 could therefore be used to prevent beta turn formation and, consequently, the formation of Abeta fibrils. Aspartic Acid amyloid beta precursor protein Homo sapiens