Title : Recreational nitrous oxide abuse-induced vitamin B12 deficiency in a patient presenting with hyperpigmentation of the skin.

Pub. Date : 2013 May

PMID : 23898268






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1 Recreational nitrous oxide abuse-induced vitamin B12 deficiency in a patient presenting with hyperpigmentation of the skin. Nitrous Oxide NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens
2 Although vitamin B12 deficiency rarely occurs in well-nourished, healthy, young people, nitrous oxide (N2O) intoxication is an important cause of vitamin B12 deficiency in this cohort. Nitrous Oxide NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens
3 Although vitamin B12 deficiency rarely occurs in well-nourished, healthy, young people, nitrous oxide (N2O) intoxication is an important cause of vitamin B12 deficiency in this cohort. Nitrous Oxide NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens
4 N2O intoxication-induced vitamin B12 deficiency was diagnosed based on the skin pigmentation that had manifested over the dorsa of her fingers, toes, and trunk, coupled with myeloneuropathy of the posterior and lateral columns, a low serum vitamin B12 level, an elevated serum homocysteine level, and the N2O exposure revealed while establishing the patient"s history. Nitrous Oxide NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens
5 N2O intoxication-induced vitamin B12 deficiency was diagnosed based on the skin pigmentation that had manifested over the dorsa of her fingers, toes, and trunk, coupled with myeloneuropathy of the posterior and lateral columns, a low serum vitamin B12 level, an elevated serum homocysteine level, and the N2O exposure revealed while establishing the patient"s history. Nitrous Oxide NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens
6 N2O intoxication-induced vitamin B12 deficiency was diagnosed based on the skin pigmentation that had manifested over the dorsa of her fingers, toes, and trunk, coupled with myeloneuropathy of the posterior and lateral columns, a low serum vitamin B12 level, an elevated serum homocysteine level, and the N2O exposure revealed while establishing the patient"s history. Nitrous Oxide NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens
7 We recommend that dermatologists consider N2O intoxication-induced vitamin B12 deficiency as a potential cause of skin hyperpigmentation and myeloneuropathy of the posterior and lateral columns in young, otherwise healthy patients. Nitrous Oxide NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens