Title : Copper transporter ATP7A protects against endothelial dysfunction in type 1 diabetic mice by regulating extracellular superoxide dismutase.

Pub. Date : 2013 Nov

PMID : 23884884






2 Functional Relationships(s)
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1 Here we show that the specific activity of SOD3, but not SOD1, is decreased, which is associated with increased O2( -) production in aortas of streptozotocin-induced and genetically induced Ins2(Akita) T1DM mice. Oxygen superoxide dismutase 3, extracellular Mus musculus
2 In summary, a decrease in ATP7A protein expression contributes to impaired SOD3 activity, resulting in O2( -) overproduction and endothelial dysfunction in blood vessels of T1DM. Oxygen superoxide dismutase 3, extracellular Mus musculus