Title : Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease.

Pub. Date : 2013

PMID : 23875003






1 Functional Relationships(s)
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1 3xTg-AD mice fed 0.23% w/v lipoic acid in drinking water for 4 weeks showed an insulin mimetic effect that consisted of increased brain glucose uptake, activation of the insulin receptor substrate and of the PI3K/Akt signaling pathway. Thioctic Acid AKT serine/threonine kinase 1 Homo sapiens