Pub. Date : 2013 Aug
PMID : 23862693
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We developed a Tet-regulated MnSOD mouse (MnSOD(tet)) to examine the detailed relationship between cellular MnSOD concentration and radioresistance and carried out in vitro studies using bone marrow culture derived stromal cell lines (mesenchymal stem cells). | tetramethylenedisulfotetramine | superoxide dismutase 2, mitochondrial | Mus musculus |
2 | We developed a Tet-regulated MnSOD mouse (MnSOD(tet)) to examine the detailed relationship between cellular MnSOD concentration and radioresistance and carried out in vitro studies using bone marrow culture derived stromal cell lines (mesenchymal stem cells). | tetramethylenedisulfotetramine | superoxide dismutase 2, mitochondrial | Mus musculus |
3 | We developed a Tet-regulated MnSOD mouse (MnSOD(tet)) to examine the detailed relationship between cellular MnSOD concentration and radioresistance and carried out in vitro studies using bone marrow culture derived stromal cell lines (mesenchymal stem cells). | tetramethylenedisulfotetramine | superoxide dismutase 2, mitochondrial | Mus musculus |
4 | Homozygous MnSOD(tet/tet) cells had low levels of MnSOD, reduced viability and proliferation, increased radiosensitivity, elevated overall antioxidant stores, and defects in cell proliferation and DNA strand-break repair. | tetramethylenedisulfotetramine | superoxide dismutase 2, mitochondrial | Mus musculus |
5 | Homozygous MnSOD(tet/tet) cells had low levels of MnSOD, reduced viability and proliferation, increased radiosensitivity, elevated overall antioxidant stores, and defects in cell proliferation and DNA strand-break repair. | tetramethylenedisulfotetramine | superoxide dismutase 2, mitochondrial | Mus musculus |
6 | Homozygous MnSOD(tet/tet) cells had low levels of MnSOD, reduced viability and proliferation, increased radiosensitivity, elevated overall antioxidant stores, and defects in cell proliferation and DNA strand-break repair. | tetramethylenedisulfotetramine | superoxide dismutase 2, mitochondrial | Mus musculus |
7 | Homozygous MnSOD(tet/tet) cells had low levels of MnSOD, reduced viability and proliferation, increased radiosensitivity, elevated overall antioxidant stores, and defects in cell proliferation and DNA strand-break repair. | tetramethylenedisulfotetramine | superoxide dismutase 2, mitochondrial | Mus musculus |
8 | Doxycycline (doxy) treatment of MnSOD(tet/tet) cells increased MnSOD levels and radioresistance from n of 2.79 +- 1.04 to 8.69 +- 1.09 (P = 0.0060) and normalized other biologic parameters. | tetramethylenedisulfotetramine | superoxide dismutase 2, mitochondrial | Mus musculus |
9 | Doxycycline (doxy) treatment of MnSOD(tet/tet) cells increased MnSOD levels and radioresistance from n of 2.79 +- 1.04 to 8.69 +- 1.09 (P = 0.0060) and normalized other biologic parameters. | tetramethylenedisulfotetramine | superoxide dismutase 2, mitochondrial | Mus musculus |
10 | Doxycycline (doxy) treatment of MnSOD(tet/tet) cells increased MnSOD levels and radioresistance from n of 2.79 +- 1.04 to 8.69 +- 1.09 (P = 0.0060) and normalized other biologic parameters. | tetramethylenedisulfotetramine | superoxide dismutase 2, mitochondrial | Mus musculus |
11 | Doxycycline (doxy) treatment of MnSOD(tet/tet) cells increased MnSOD levels and radioresistance from n of 2.79 +- 1.04 to 8.69 +- 1.09 (P = 0.0060) and normalized other biologic parameters. | tetramethylenedisulfotetramine | superoxide dismutase 2, mitochondrial | Mus musculus |
12 | In contrast, MnSOD(tet/tet) cells showed minimal difference in baseline and radiation induced mRNA and protein levels of TGF-beta, Nrf2 and NF-kappaB and radiation induced cell cycle arrest was not dependent upon MnSOD level. | tetramethylenedisulfotetramine | superoxide dismutase 2, mitochondrial | Mus musculus |
13 | In contrast, MnSOD(tet/tet) cells showed minimal difference in baseline and radiation induced mRNA and protein levels of TGF-beta, Nrf2 and NF-kappaB and radiation induced cell cycle arrest was not dependent upon MnSOD level. | tetramethylenedisulfotetramine | superoxide dismutase 2, mitochondrial | Mus musculus |
14 | These novel MnSOD(tet/tet) mouse derived cells should be valuable for elucidating several parameters of the oxidative stress response to ionizing radiation. | tetramethylenedisulfotetramine | superoxide dismutase 2, mitochondrial | Mus musculus |
15 | These novel MnSOD(tet/tet) mouse derived cells should be valuable for elucidating several parameters of the oxidative stress response to ionizing radiation. | tetramethylenedisulfotetramine | superoxide dismutase 2, mitochondrial | Mus musculus |