Title : Conditional radioresistance of Tet-inducible manganese superoxide dismutase bone marrow stromal cell lines.

Pub. Date : 2013 Aug

PMID : 23862693






15 Functional Relationships(s)
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1 We developed a Tet-regulated MnSOD mouse (MnSOD(tet)) to examine the detailed relationship between cellular MnSOD concentration and radioresistance and carried out in vitro studies using bone marrow culture derived stromal cell lines (mesenchymal stem cells). tetramethylenedisulfotetramine superoxide dismutase 2, mitochondrial Mus musculus
2 We developed a Tet-regulated MnSOD mouse (MnSOD(tet)) to examine the detailed relationship between cellular MnSOD concentration and radioresistance and carried out in vitro studies using bone marrow culture derived stromal cell lines (mesenchymal stem cells). tetramethylenedisulfotetramine superoxide dismutase 2, mitochondrial Mus musculus
3 We developed a Tet-regulated MnSOD mouse (MnSOD(tet)) to examine the detailed relationship between cellular MnSOD concentration and radioresistance and carried out in vitro studies using bone marrow culture derived stromal cell lines (mesenchymal stem cells). tetramethylenedisulfotetramine superoxide dismutase 2, mitochondrial Mus musculus
4 Homozygous MnSOD(tet/tet) cells had low levels of MnSOD, reduced viability and proliferation, increased radiosensitivity, elevated overall antioxidant stores, and defects in cell proliferation and DNA strand-break repair. tetramethylenedisulfotetramine superoxide dismutase 2, mitochondrial Mus musculus
5 Homozygous MnSOD(tet/tet) cells had low levels of MnSOD, reduced viability and proliferation, increased radiosensitivity, elevated overall antioxidant stores, and defects in cell proliferation and DNA strand-break repair. tetramethylenedisulfotetramine superoxide dismutase 2, mitochondrial Mus musculus
6 Homozygous MnSOD(tet/tet) cells had low levels of MnSOD, reduced viability and proliferation, increased radiosensitivity, elevated overall antioxidant stores, and defects in cell proliferation and DNA strand-break repair. tetramethylenedisulfotetramine superoxide dismutase 2, mitochondrial Mus musculus
7 Homozygous MnSOD(tet/tet) cells had low levels of MnSOD, reduced viability and proliferation, increased radiosensitivity, elevated overall antioxidant stores, and defects in cell proliferation and DNA strand-break repair. tetramethylenedisulfotetramine superoxide dismutase 2, mitochondrial Mus musculus
8 Doxycycline (doxy) treatment of MnSOD(tet/tet) cells increased MnSOD levels and radioresistance from n of 2.79 +- 1.04 to 8.69 +- 1.09 (P = 0.0060) and normalized other biologic parameters. tetramethylenedisulfotetramine superoxide dismutase 2, mitochondrial Mus musculus
9 Doxycycline (doxy) treatment of MnSOD(tet/tet) cells increased MnSOD levels and radioresistance from n of 2.79 +- 1.04 to 8.69 +- 1.09 (P = 0.0060) and normalized other biologic parameters. tetramethylenedisulfotetramine superoxide dismutase 2, mitochondrial Mus musculus
10 Doxycycline (doxy) treatment of MnSOD(tet/tet) cells increased MnSOD levels and radioresistance from n of 2.79 +- 1.04 to 8.69 +- 1.09 (P = 0.0060) and normalized other biologic parameters. tetramethylenedisulfotetramine superoxide dismutase 2, mitochondrial Mus musculus
11 Doxycycline (doxy) treatment of MnSOD(tet/tet) cells increased MnSOD levels and radioresistance from n of 2.79 +- 1.04 to 8.69 +- 1.09 (P = 0.0060) and normalized other biologic parameters. tetramethylenedisulfotetramine superoxide dismutase 2, mitochondrial Mus musculus
12 In contrast, MnSOD(tet/tet) cells showed minimal difference in baseline and radiation induced mRNA and protein levels of TGF-beta, Nrf2 and NF-kappaB and radiation induced cell cycle arrest was not dependent upon MnSOD level. tetramethylenedisulfotetramine superoxide dismutase 2, mitochondrial Mus musculus
13 In contrast, MnSOD(tet/tet) cells showed minimal difference in baseline and radiation induced mRNA and protein levels of TGF-beta, Nrf2 and NF-kappaB and radiation induced cell cycle arrest was not dependent upon MnSOD level. tetramethylenedisulfotetramine superoxide dismutase 2, mitochondrial Mus musculus
14 These novel MnSOD(tet/tet) mouse derived cells should be valuable for elucidating several parameters of the oxidative stress response to ionizing radiation. tetramethylenedisulfotetramine superoxide dismutase 2, mitochondrial Mus musculus
15 These novel MnSOD(tet/tet) mouse derived cells should be valuable for elucidating several parameters of the oxidative stress response to ionizing radiation. tetramethylenedisulfotetramine superoxide dismutase 2, mitochondrial Mus musculus