Pub. Date : 2013
PMID : 23861949
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celastrol inhibits lipopolysaccharide-stimulated rheumatoid fibroblast-like synoviocyte invasion through suppression of TLR4/NF-kappaB-mediated matrix metalloproteinase-9 expression. | celastrol | toll like receptor 4 | Homo sapiens |
| 2 | Furthermore, our results revealed that celastrol inhibited the transcriptional activity of MMP-9 by suppressing the binding activity of NF-kappaB in the MMP-9 promoter, and suppressed the TLR4/MyD88/NF-kappaB pathway. | celastrol | toll like receptor 4 | Homo sapiens |
| 3 | In conclusion, celastrol might inhibit FLS migration and invasion induced by LPS by suppressing TLR4/NF-kappaB-mediated MMP-9 expression, providing a theoretical foundation for the clinical treatment of RA with celastrol. | celastrol | toll like receptor 4 | Homo sapiens |
| 4 | In conclusion, celastrol might inhibit FLS migration and invasion induced by LPS by suppressing TLR4/NF-kappaB-mediated MMP-9 expression, providing a theoretical foundation for the clinical treatment of RA with celastrol. | celastrol | toll like receptor 4 | Homo sapiens |