Title : The carbonylation and covalent dimerization of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity is inhibited by the radical scavenger tempol.

Pub. Date : 2013 Oct 1

PMID : 23855710






2 Functional Relationships(s)
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Protein Name
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1 The chosen oxidizing system was the bicarbonate-dependent peroxidase activity of hSOD1 that consumes H2O2 to produce carbonate radical, which oxidizes the enzyme. Bicarbonates superoxide dismutase 1 Homo sapiens
2 Tempol consumption by the bicarbonate-dependent peroxidase activity of hSOD1 may be one of the reasons why high doses of tempol were required to afford protection in an ALS rat model. Bicarbonates superoxide dismutase 1 Homo sapiens