Pub. Date : 2013 Aug 23
PMID : 23853094
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The primary structure of Foxp3 contains four cyclin-dependent kinase (CDK) motifs (Ser/Thr-Pro) within the N-terminal repressor domain, and we show that CDK2 can partner with cyclin E to phosphorylate Foxp3 at these sites. | Serine | cyclin dependent kinase 2 | Homo sapiens |
| 2 | Consistent with our previous demonstration that CDK2 negatively regulates Treg function, we find that mutation of the serine or threonine at each CDK motif to alanine (S/T A) results in enhanced Foxp3 protein stability in CD4(+) T cells. | Serine | cyclin dependent kinase 2 | Homo sapiens |