Title : Effects of cytochrome P450 inhibitors and inducers on the metabolism and pharmacokinetics of ospemifene.

Pub. Date : 2013 Oct

PMID : 23852652






2 Functional Relationships(s)
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1 Roles for CYP3A4, CYP2C9, CYP2C19 and CYP2B6 in the metabolism of ospemifene and its two main metabolites, 4--hydroxyospemifene and 4"-hydroxyospemifene, were confirmed. Ospemifene cytochrome P450 family 2 subfamily C member 9 Homo sapiens
2 Strong CYP3A or CYP2C9 inducers (e.g. rifampicin) would be expected to decrease the exposure to ospemifene. Ospemifene cytochrome P450 family 2 subfamily C member 9 Homo sapiens