Title : Cholinergic receptors modulate immune complex-induced inflammation in vitro and in vivo.

Pub. Date : 2013 Aug 15

PMID : 23851693






1 Functional Relationships(s)
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1 In this study, we show that stimulation of alpha7nAChR on human polymorphonuclear neutrophils (PMNs) and blood mononuclear phagocytes in vitro attenuates C5aR- and FcgammaR-triggered generation of reactive oxygen species, expression of leukocyte markers involved in cell recruitment and adhesion, and release of TNF-alpha and other proinflammatory cytokines. Reactive Oxygen Species cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus